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Age-related macular generation (AMD) is an emerging visual morbidity world over. With an aging population in India this disease gains significance like diabetes, cancer and cardio-vascular diseases. Few specific genetic factors so far have been identified for this major age-related ocular problem, like complement factor H (CFH) to be associated with the disease in the Western population. We would recruit 250 each of age-matched cases and controls and do high density single nucleotide polymorphism (SNP) based haplotype mapping of AMD candidate regions of the human genome and also would look at the SNPs association with AMD candidate genes . The outcome of the study would throw tremendous insight into our fundamental knowledge of the disease and its specific role in etiopathogenesis in our population. Besides the results obtained could also evolve into diagnostic test for predictive testing and could device a probable interventional method that could delay the onset of the disease.
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