The corneal endothelial dystrophies, which are due to primary dysfunction of the endothelium, are congenital hereditary endothelial dystrophy (CHED), Fuch's corneal dystrophy (FCD) and posterior polymorphous corneal dystrophy (PPCD/PPD). Linkage studies on multigenerational early onset FCD families have identified COL8A2 to be the candidate gene. SLC4A11 gene has been identified to be the candidate gene for autosomal recessive CHED (CHED2). We would do mutation screening for COL8A2 and SLC4A11 genes in confirmed FCD and CHED patients and linkage analysis in FCD families to identify new genes responsible for this disease