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Sankara Nethralaya
Sankara Nethralaya
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Department of Larsen & Toubro Ocular Pathology
Projects
Research Projects - Retinoblastoma

I. To evaluate the in vitro efficacy of PLGA-nanoparticles encapsulated with chemotherapeutic drugs to induce apoptosis in Y79 retinoblastoma cell line

The project is useful in studying the invitro efficacy of PLGA nanoparticles encapsulated with chemotherapeutic drugs(etoposide, doxorubicin, vincristine) to induce apoptosis in Y79 retinoblastoma cell line.

II. Efficacy of EpCAM-conjugated drug loaded biodegradable nanoparticles for drug therapy in Retinoblastoma

This project helps in studying the efficacy of Epcam antibody conjugated drug loaded biodegradable Nanoparticles for drug therapy in Retinoblastoma cell line.

III. Developing Molecularly targeted polymer Nanoparticles for cancer diagnostics and Therapeutics.

This project is about to make a novel aptamer against EpCAM molecule which is found to be over expressed in majority of epithelial careers including retinoblastoma. This aptamer should block functional property of EpCAM.

IV. HMGA2 gene is a promising target for therapy in Retinoblastoma by RNA Interference

In this study, we have proposed to work on the silencing of the HMGA2 gene, which would enable us to identify it as the promising target to combat retinoblastoma.

V. “Phase I Clinical trial: Sub-conjunctival in Fibrin Sealant in Patients with Advanced retinoblastoma”

This project is used to study the maximum tolerated dose of carboplatin in fibrin sealant in Indian children with retinoblastoma.

VI. To investigate the effect of Tiam1 siRNA on Tumor cell survival and proliferation in Retinoblastoma.

This project is used to study the molecular mechanisms that lead to invasiveness in retinoblastoma tumors and to rule out preventive and therapeutic strategies.